The global pharmaceutical industry is in the midst of a business model transition. In the article Building a Foundation for the Future: Reflecting on the State of the Pharmaceutical Business Model, excerpted from Healthcare at a Turning Point: A Roadmap for Change, President Rita E. Numerof, Ph.D. explains how the current pharmaceutical business model is shifting. Along with this shift, pharmaceutical companies are facing the challenge of balancing between the old model, which still appears to have a life, and the new model, which is underdeveloped and unproven.